Researchers at the Francis Crick Institute have discovered a significant new cause of Inflammatory Bowel Disease (IBD).

Through genetic analysis, they identified a section of DNA that is active in macrophages, a type of immune cell that causes inflammation in people with IBD.

This DNA section is a key controller of macrophages, enhancing a gene called ETS2, which regulates the inflammatory chemicals released by macrophages.

Higher levels of ETS2 are linked to increased gut inflammation.

Some individuals have a version of this genetic code that makes their bodies more prone to overreacting to inflammatory stimuli.

Currently, there are no medicines specifically designed to block ETS2.

However, there are existing medications for other conditions that could potentially inhibit the inflammatory effects of ETS2.

These medications, known as MEK inhibitors, could theoretically reduce gut inflammation in people with IBD.

However, MEK inhibitors can have serious side effects on other parts of the body.

Therefore, the next phase of research is to find ways to target MEK inhibitors specifically to macrophages in the gut.

Starting with genetics, researchers have uncovered a pathway that seems to play a major role in IBD and other inflammatory diseases.

Excitingly, they have demonstrated that this pathway can be targeted therapeutically, and they are now working on ensuring this approach is safe and effective for future treatments.

Any changes in treatment resulting from this research for people with Crohn's or Colitis are likely several years away.

However, researchers worldwide will be interested in this study and its implications for future treatments.

The more we understand about Inflammatory Bowel Disease, the better we can help patients live well with these conditions.

This research is a significant step towards the possibility of a world free from Crohn's and Colitis one day.

Crohn’s & Colitis UK are proud to have funded this work.

Thank you to all our supporters and members who enable us to fund and support exciting research like this study.

We know it can be challenging to live with or support someone living with these conditions, but you are not alone.

We provide up-to-date, evidence-based information and can support you in living well with Crohn’s or Colitis.

Please note that we are not medically or legally trained and cannot provide detailed financial or benefits advice or specialist emotional support.

Please contact us via telephone, email, or Live Chat from 9 am to 5 pm, Monday to Friday (except English bank holidays).

If you need specific medical advice about your condition, your GP or IBD team will be best placed to help.

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We provide up-to-date, evidence-based information and can support you in living well with Crohn’s or Colitis.

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