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they are featuring at this stage for the sixth time in seven seasons.
The Blauw-Zwart missed out last term, though, just one year after finally reaching the knockout phase, where they were thumped by Benfica in the last 16.
Their reward for winning the Belgian Pro League last season was a tough draw this time around, as AC Milan and Manchester City are also among their upcoming opponents.
With eight points estimated to be sufficient for a place in the playoffs, there is everything to play for, particularly after enjoying a deep run through UEFA's third-tier competition in 2023-24.
In the Europa Conference League, Club Brugge came through three qualifiers and then won five of six group games, before seeing off Molde and PAOK in the knockout rounds; however, Fiorentina then won by the odd goal in seven over the course of a close-fought semi-final tie.
Brugge were unbeaten at home in Europe last season, and strong form at Jan Breydel Stadium also helped them become champions of Belgium for the 19th time, securing a fourth league title in five years.
After leading them to top spot, 's interim role was made permanent during the summer, and his team are currently again, having won four of their first seven matches - including at Kortrijk last week, when scored twice in a 3-0 success.
After summer signing made his first Borussia Dortmund start last time out, having recovered from a knee injury sustained while on international duty, the Guinea striker will vie with to feature up front in midweek.
It has been a scintillating start to September for another BVB forward, Karim Adeyemi, who not only scored five goals in two games for Germany Under-21s but then bagged a Bundesliga brace on Friday evening.
Brazilian full-back was forced to withdraw from the Brazil squad due to injury but returned as a substitute against Heidenheim; however, USA star could miss out again because of a groin problem.
Danish winger is the hosts' top scorer this season on three goals, while teenager has broken into the squad and scored as a substitute at the weekend.
Captain Hans Vanaken - the Blau-Zwart's top appearance maker in the Champions League (38) - was directly involved in seven goals during their run to last term's Conference League semi-finals, scoring six of his own and providing one assist.
Mignolet; Seys, Mechele, Ordonez, De Cuyper; Onyedika, Vetlesen; Skov Olsen, Vanaken, Tzolis; Nilsson.
Borussia Dortmund kept the most clean sheets in last season's Champions League (six), but Club Brugge have scored freely this term and have a potent frontline with which to test their visitors.
The hosts should score, though Dortmund may still leave Belgium with maximum points, having looked pretty solid since Nuri Sahin took over.
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